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Oct 24, Ten New Genetic Links Found That May Link To Eczema
It has been reported that ten new genetic links have been discovered that may increase the risk of eczema developing. Amongst the genes found, were some that had an effect on certain roles of the immune system. An over-active immune system can be a cause of cause developing. The first part of the research was done with around 21,000 eczema sufferers and over 90,000 non-sufferers. Another 260,000 people were added to the research so the results could be confirmed. The main result of the study confirms how important the immune system is in the development of eczema. How these new found genes will increase the risk of eczema developing may need more research, and more time.
Eczema Blog
Jan 14, Link Between Immune System and Food Allergies
A research team in Australia have discovered that there is a link between children who have an over-active immune system, and the development of certain food allergies. They found that children who have an over-active immune system are more likely to develop food allergies in the first few years of life. They aren’t sure why certain children have hyperactive immune cells, though they have found that certain cells are activated before or during birth. Why it happens is unknown. They are going to carry on the research to look for answers that may help to lower the risk of children developing these food allergies.
Eczema Blog
Link between cancer and obesity higher in women
As someone who has recently lost weight (22 pounds or 9.7kg in new money) I was interested to read a recent study published in The Lancet.
A recent cancer diagnosis within my family made me stop and think. I’m middle-aged and clearly I wasn’t doing myself any favours by being overweight, potentially storing up problems for later in life. And I felt pretty miserable actually as I knew I owed it to myself to look and feel better. I still have a bit of weight I’d like to lose, but the difference the weight loss has made is not to be under-estimated.
The study in The Lancet shows a clear link between obesity and cancer. The US Centers for Disease Control and Prevention released their report on cancer and obesity last week. It highlights that cancers associated with being overweight and obese, including thyroid, liver, kidney, and ovarian cancer, account for 40% of cancers diagnosed in the USA, with over 630,000 diagnoses in 2014 alone.
The study looked at data from the United States Cancer Statistics for 2005-2014. Disparities between sexes in the rates of cancers associated with obesity are especially frightening, with 55% of all cancers diagnosed in women being associated with overweight and obesity, compared with only 24% of cancers in men.
And, the likelihood is that these trends will be similar in the UK so we need to take note.
Losing weight isn’t easy and it takes time. And as well as losing the weight it’s important to eat a healthy, low calorie diet, get plenty of sleep and exercise. It has to be approached holistically. There are also some great apps out there to help you monitor your food intake, weight loss, sleep and exercise.
But, before embarking on any changes in nutrition and exercise, it is advisable to see your GP.
For more information about this study and the link between cancer and obesity, click here
Study casts doubt about link between eczema, cardiovascular disease
For the roughly 7 percent of adults who live with atopic dermatitis, a common form of eczema, a new study reports a little good news: Despite recent findings to the contrary, the skin condition is…
Eczema / Psoriasis News From Medical News Today
Study casts doubt about link between eczema, cardiovascular disease
For the roughly 7 percent of adults who live with atopic dermatitis, a common form of eczema, a new study reports a little good news: Despite recent findings to the contrary, the skin condition is…
Eczema / Psoriasis News From Medical News Today
Study casts doubt about link between eczema, cardiovascular disease – EurekAlert (press release)
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Study casts doubt about link between eczema, cardiovascular disease
EurekAlert (press release) PROVIDENCE, R.I. [Brown University] — For the roughly 7 percent of adults who live with atopic dermatitis, a common form of eczema, a new study reports a little good news: Despite recent findings to the contrary, the skin condition is likely not … |
Surprising link found in black women breast cancer risk
Alcohol consumption is known to be a risk factor for breast cancer based on studies predominantly done in white women. Now, a University of North Carolina Lineberger Comprehensive Cancer Center study has found the same risk exists for black women.
Managed Healthcare Executive – Health Management
A Link Between Atherosclerosis And Autoimmunity
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Main Category: Cardiovascular / Cardiology
Also Included In: Immune System / Vaccines;??Eczema / Psoriasis;??Lupus
Article Date: 09 Apr 2012 – 0:00 PST Current ratings for:
A Link Between Atherosclerosis And Autoimmunity 
Individuals who suffer from autoimmune diseases also display a tendency to develop atherosclerosis – the condition popularly known as hardening of the arteries. Clinical researchers at LMU, in collaboration with colleagues in Wurzburg, have now discovered a mechanism which helps to explain the connection between the two types of disorder. The link is provided by a specific class of immune cells called plasmacytoid dendritic cells (pDCs). pDCs respond to DNA released from damaged and dying cells by secreting interferon proteins which stimulate the immune reactions that underlie autoimmune diseases. The new study shows that stimulation of pDCs by a specific DNA-protein complex contributes to the progression of atherosclerosis. The findings may have implications for new strategies for the treatment of a whole spectrum of conditions that are associated with chronic inflammatory reactions.
Atherosclerosis is a major cause of death in Western societies. The illness is due to the formation of insoluble deposits called atherosclerotic plaques on the walls of major arteries as a consequence of chronic, localized inflammation reactions. By reducing blood flow, the plaques can provoke heart attacks and strokes. A class of immune cells called dendritic cells plays a crucial role in facilitating the development of these plaques. The term refers to a heterogeneous cell population that makes up part of the immune system. Among the cell types represented in this population are the so-called plasmacytoid dendritic cells (pDC), but their potential significance for atherosclerosis had not been explored until now. A group of researchers led by Dr. Yvonne Doring in Professor Christian Weber’s department at LMU, together with a team supervised by Privatdozentin Dr. Alma Zernecke of Wurzburg University, has now shown how pDCs promote the development of atherosclerosis – and explained why patients with autoimmune disorders, such as psoriasis or systemic lupus erythematodes (SLE), show a predisposition to atherosclerosis.
Using laboratory mice as an experimental model, the researchers were able to show that pDCs contribute to early steps in the formation of athersclerotic lesions in the blood vessels. Stimulation of pDCs causes them to secrete large amounts of interferons, proteins that strongly stimulate inflammatory processes. The protein that induces the release of interferons is produced by immune cells that accumulate specifically at sites of inflammation, and mice that are unable to produce this protein also have fewer plaques. Stimulation of pDCs in turn leads to an increase in the numbers of macrophages present in plaques. Macrophages normally act as a clean-up crew, removing cell debris and fatty deposits by ingesting and degrading them. However, they can also “overindulge”, taking up more fat than they can digest. When this happens, they turn into so-called foam cells that promote rather than combat atherosclerosis. In addition, activated, mature pDCs can initiate an immune response against certain molecules found in atherosclerotic lesions, which further exacerbates the whole process.
The stimulation of pDCs provides the link between atherosclerosis and autoimmune diseases. “The pDCs themselves are stimulated by the self-antigens that set off the autoimmune reactions which result in conditions like psoriasis and SLE,” says Doring. Indeed, it is well known that the secretion of interferons by activated pDCs contributes to the genesis of a number of autoimmune diseases
“The newly discovered involvement of pDCs in the development of atherosclerosis establishes a direct link between this disorder and autoimmune reactions, and reveals why the stimulation of pDC that is characteristic of autoimmune diseases contributes to the progression of atherosclerosis,” says Weber. “The findings also suggest new approaches to the treatment of chronic inflammation that could be useful for a whole range of diseases.”
Article adapted by Medical News Today from original press release. Click ‘references’ tab above for source.Visit our cardiovascular / cardiology section for the latest news on this subject. Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis
Y. Doring, H. Manthey, M. Drechsler, D. Lievens, R. Megens, O. Soehnlein, M. Busch, M. Manca, R. R. Koenen, J. Pelisek, M. J. Daemen, E. Lutgens, M. Zenke, C. J. Binder, C. Weber, A. Zernecke
Circulation published online March 2, 2012
http://circ.ahajournals.org/content/early/2012/03/02/CIRCULATIONAHA.111.046755
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Link Between Severe Psoriasis And Increased Risk For Diabetes
AppId is over the quota AppId is over the quota Main Category: Eczema / Psoriasis
Also Included In: Diabetes
Article Date: 17 Oct 2012 – 0:00 PST Current ratings for:
Link Between Severe Psoriasis And Increased Risk For Diabetes 
An analysis of 27 studies linking psoriasis in 314,000 individuals with diabetes has found strong correlation between the scaly skin rash and the blood sugar disorder that predisposes patients to heart disease, say UC Davis researchers who led the review.
The findings appear in an article titled “Psoriasis and the risk of diabetes: a systematic review and meta-analysis,” which is now online in the Archives of Dermatology.
“Our investigation found a clear association between psoriasis and diabetes,” said April Armstrong, assistant professor of dermatology at UChttp://www.eczemablog.net/ Davis and principal investigator of the study. “Patients with psoriasis and their physicians need to be aware of the increased risk of developing diabetes so that patients can be screened regularly and benefit from early treatment.”
Psoriasis is a common skin problem that tends to run in families. It causes a raised red, flaky and sometimes itchy rash, often on the elbows and knees, although it can appear anywhere. It is believed to be an autoimmune disease, in which the body regards its own skin as foreign and mounts an inflammatory response.
Armstrong and her colleagues combined data from 27 observational studies of patients with psoriasis, in what is known as a meta-analysis. Five of the studies assessed the incidence of diabetes – that is, how many patients with psoriasis developed diabetes during the course of a study, which ranged from 10 to 22 years. The other studies assessed the prevalence of diabetes – how many patients already had diabetes at the outset of a study. Altogether, the studies evaluated more than 314,000 people with psoriasis and compared them to 3.7 million individuals (controls) without the disease.
Some of the studies classified patients by disease severity. The aggregate data for these studies showed that patients with mild psoriasis are over 1.5 times more likely to have diabetes than the general population while those with severe disease are nearly twice as likely. Among studies that assessed incidence, patients with psoriasis had a 27 percent increased risk of developing diabetes compared with the general population.
All but one study analyzing incidence found a link between psoriasis and diabetes. These studies included patient data from outpatient clinics, insurance claims and hospitals. Diabetes rates were similar in patients despite ethnicity or country where the study was conducted.
“The large sample size and consistent association between psoriasis and diabetes make these study findings very strong and suggest an underlying physiological link between the two diseases,” said Armstrong, who directs the Dermatology Clinical Research Unit at UC Davis and the teledermatology program.
While additional research is need to understand how the two diseases are associated, Armstrong believes altered immune pathways may make psoriasis patients more susceptible to developing diabetes.
“There is evidence that fat cells in psoriasis patients may not function normally,” she said. “These cells secrete inflammatory substances known as cytokines that increase insulin resistance in the liver and muscle and initiate destruction of insulin-producing cells in the pancreas.”
Additional research will also clarify other potential limiting factors in the current study. For example, the study’s authors noted that epidemiological or observational studies can be susceptible to confounding factors, such as concurrent medications used to treat psoriasis that may modulate the risk of developing diabetes.
Armstrong’s study adds to a growing body of research that shows psoriasis is not just skin deep. “We know patients with psoriasis and hypertension tend to require more aggressive therapy to bring their blood pressure under control,” said Armstrong. “We also know that psoriasis patients have higher rates of heart attacks, strokes and cardiovascular-related deaths than the general population. Primary-care physicians need to be aware of these underlying predispositions to disease to provide the best care to their patients.”
Armstrong and her colleagues plan to examine endothelial cells – cells that line blood vessels – to better understand the underlying physiological basis of psoriasis. They also are collaborating with other research institutions to develop a network to share clinical data on patients with psoriasis.
Article adapted by Medical News Today from original press release. Click ‘references’ tab above for source.Visit our eczema / psoriasis section for the latest news on this subject. The study’s other authors were Caitlin Harskamp, also of the UC Davis Department of Dermatology, and Ehrin Armstong, an interventional cardiologist with the UC Davis Division of Cardiovascular Medicine. Armstrong and her colleagues also received training and support for their systematic review and meta-analysis from the UC Davis Center for Healthcare Policy and Research.
University of California – Davis Health System Please use one of the following formats to cite this article in your essay, paper or report:
MLA
7 Apr. 2013.
Please note: If no author information is provided, the source is cited instead.
‘Link Between Severe Psoriasis And Increased Risk For Diabetes’
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View the original article here
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